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구강 편평 상피 암종에서 TGF-β1과 MMP-2의 발현과 경부 임파절 전이 간의 상관 관계에 관한 연구
THE CLINICAL SIGNIFICANCE OF THE EXPRESSION OF TGF-β1 AND MMP-2 RELATED TO THE REGIONAL LYMPH NODE ETASTASIS IN THE ORAL SQUAMOUS CELL CARCINOMA

대한구강악안면외과학회지 2007년 33권 3호 p.199 ~ 203

김좌영, 김성곤, Rotaru Horatiu,

소속 상세정보

김좌영 ( Kim Jwa-Young ) - 한림대학교 성심병원 구강악안면외과학교실
김성곤 ( Kim Seong-Gon ) - 한림대학교 의과대학 구강외과학교실
( Rotaru Horatiu ) - 루마니아 Iuliu Hatieganu Hatieganu University

KMID : 0355620070330030199

Abstract

Several matrix metalloproteinases (MMPs) have been shown to play an important role in the invasion and metastasis of oral squamous cell carcinoma (OSCC). The members of the TGF-βsignaling pathway are being considered as predictive biomarkers for progressive tumorigenesis and molecular targets for the prevention and the treatment of cancer and metastasis. The aim of the present study was to find the clinical significance of the expression of TGF-β1 and MMP-2 related to the regional lymph node metastasis in OSCC. This study included 76 cases of primary OSCC, of which 42 cases showed regional lymph node metastases. Immunohistochemistry was used for the localization of protein. The relation between the expression of each protein and clinical variables was statistically evaluated. In results, the expression of TGF-β1 both main mass with lymph node metastasis and without lymph node metastasis was found not to be statistically significant (p＞0.05). The expression of MMP-2 was found to be statistically significant related to regional lymph node metastasis (p＜0.05). When compared the expression in the metastatic lymph node, TGF-β1 was significantly highly expressed than MMP-2 (p＜0.05). In conclusion, the expression of MMP-2 was significantly elevated in patients with lymph node metastasis as compared to the patients without lymph node metastasis, which could be useful in predicting the risk of lymph node metastasis in OSCC.